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RNMTL1 antibody

Cat.#: 114769

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Special Price 239.0 USD

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Product Information

  • Product Name
    RNMTL1 antibody
  • Documents
  • Description
    RNMTL1 Rabbit Polyclonal antibody. Positive IHC detected in human liver. Positive WB detected in HeLa cells, HEK-293 cells. Observed molecular weight by Western-blot: 47kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    human, mouse, rat; other species not tested.
  • Alternative names
    RNMTL1 antibody; RNA methyltransferase like 1 antibody; HC90 antibody; FLJ10581 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of RNMTL1 recombinant protein (Accession Number: NM_018146). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:1000-1:10000

    IHC: 1:20-1:200

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:114769(RNMTL1 antibody) at dilution of 1:500

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:114769(RNMTL1 antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human liver using Catalog No:114769(RNMTL1 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human liver using Catalog No:114769(RNMTL1 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human liver using Catalog No:114769(RNMTL1 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human liver using Catalog No:114769(RNMTL1 antibody) at dilution of 1:100 (under 40x lens)

  • Background
    The RNA methyltransferase like 1 gene (RNMTL1) is one of thirteen newly discovered genes within a 116 Kb segment of the chromosome 17p13.3, which suffers from a high frequent loss of heterozygosity in human hepatocellular carcinoma. Its amino acid sequence was identified a high conserved region with methylases from various microorganisms, suggesting to have function to transfer methyl group to rRNA molecule [PMID:12296377].
  • References
    • Lee KW, Okot-Kotber C, LaComb JF, Bogenhagen DF. Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid. The Journal of biological chemistry. 288(43):31386-99. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"