RNF40 antibody

RNF40 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

RNF40 Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, mouse liver tissue, mouse lung tissue, mouse spleen tissue. Observed molecular weight by Western-blot: 114kd

ELISA, WB

human, mouse, rat; other species not tested.

RNF40 antibody; RBP95 antibody; BRE1 B antibody; STARING antibody; BRE1B antibody

Rabbit IgG

This antibody was obtained by immunization of RNF40 recombinant protein (Accession Number: NM_001286572). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The DNA damage response (DDR) is emerging as a vast signaling network that temporarily modulates numerous aspects of cellular metabolism in the face of DNA lesions, especially critical ones such as the double strand break (DSB). The DDR involves extensive dynamics of protein post-translational modifications, most notably phosphorylation and ubiquitylation. A recently identified novel component of the DDR pathway - histone H2B monoubiquitylation - exemplifies this principle. Monoubiquitination of histone H2B is a dynamic post-translational histone modification associated with transcriptional elongation and the DNA damage response [PMID:22021426]. In mammalian cells, H2B monoubiquitylation is driven primarily by an E3 ubiquitin ligase composed of the two RING finger proteins RNF20 and RNF40 [PMID:22031019,21827756].