RNF4 antibody

RNF4 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

RNF4 Rabbit Polyclonal antibody. Positive IP detected in PC-3 cells. Observed molecular weight by Western-blot: 30 kDa

ELISA, IP

Human,Mouse,Rat; other species not tested.

E3 ubiquitin ligase RNF4 antibody; Protein SNURF antibody; RES4 26 antibody; ring finger protein 4 antibody; RNF4 antibody; SNURF antibody

Rabbit IgG

This antibody was obtained by immunization of RNF4 recombinant protein (Accession Number: NM_001185009). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

RNF4 is a E3 ubiquitin-protein ligase that binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. It regulates the degradation of several proteins including PML and PEA3[PMID:18408734]. It also participates in chromosome alignment and spindle assembly, and regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. In addition, RNF4 can regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1 [PMID:20026589]. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation [PMID:11319220]. RNF4 exist as two isoforms. Isoform one is a 30 kDa protein and isoform two is a about 15 kDa protein.