RIOK3 Polyclonal Antibody

Cat.#: 164294

Special Price 290.3 USD

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Product Information

  • Product Name
    RIOK3 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to RIOK3
  • Tested applications
    WB
  • Species reactivity
    Human
  • Alternative names
    RIOK3 antibody; SUDD antibody; RIO kinase 3 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic Peptide of human RIOK3
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, pH7.3.
  • Storage instructions
    Store at 4℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:1000
  • Validations

    Western blot - RIOK3 Polyclonal Antibody

    Western blot - RIOK3 Polyclonal Antibody

    Western blot analysis of extracts of HeLa cells, using RIOK3 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.

  • Background
    Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"