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  • RIC8B antibody
  • RIC8B antibody
  • RIC8B antibody

RIC8B antibody

Cat.#: 114699

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Special Price 239.0 USD

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Product Information

  • Product Name
    RIC8B antibody
  • Documents
  • Description
    RIC8B Rabbit Polyclonal antibody. Positive IHC detected in human brain tissue. Positive WB detected in human brain tissue. Observed molecular weight by Western-blot: 61-66kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    FLJ10620 antibody; hSyn antibody; RIC8 antibody; RIC8B antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of RIC8B recombinant protein (Accession Number: BC034220). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:114699(RIC8B antibody) at dilution of 1:1000

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:114699(RIC8B antibody) at dilution of 1:1000

    Immunohistochemical of paraffin-embedded human brain using Catalog No:114699(RIC8B antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:114699(RIC8B antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:114699(RIC8B antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:114699(RIC8B antibody) at dilution of 1:100 (under 40x lens)

  • Background
    Ric8, also known as synembryn, is a guanine nucleotide exchange factor (GEF) that enhances variegated G protein signaling pathways, including Gα(q) and Gα(s) regulation of neurotransmission, Gα(i)-dependent mitotic spindle positioning during (asymmetric) cell division, and Gα(olf)-dependent odorant receptor signaling (PMID: 21467038). In mammals, two Ric8 homologues have been reported (Ric8A and Ric8B). Ric8B is able to potentiate G(s)/G(olf) signaling (PMID: 15829631; 16754875; 20133939).
  • References
    • Fenech C, Patrikainen L, Kerr DS. Ric-8A, a Galpha protein guanine nucleotide exchange factor potentiates taste receptor signaling. Frontiers in cellular neuroscience. 3:11. 2009.
    • Saare M, Lulla S, Tõnissoo T. Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis. PloS one. 10(6):e0129131. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"