RIC8A Polyclonal Antibody

Cat.#: 164416

Special Price 290.3 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    RIC8A Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to RIC8A
  • Tested applications
    WB
  • Species reactivity
    Human
  • Alternative names
    RIC8A antibody; RIC8 antibody; synembryn-A antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic Peptide of human RIC8A
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, pH7.3.
  • Storage instructions
    Store at 4℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:1000
  • Validations

    Western blot - RIC8A Polyclonal Antibody

    Western blot - RIC8A Polyclonal Antibody

    Western blot analysis of extracts of A2058 cells, using RIC8A antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.

  • Background
    Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"