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  • RI-EXT

RI-EXT

Cat.#: 318874

Size:
Optional Service: TFA RemovalWhat's this?

Special Price 299 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    RI-EXT
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    ffGGreGcvlylaevlhsG (lower case letters on behalf of D-amino acid)
  • Three letter code
    H-D-Phe-D-Phe-Gly-Gly-D-Arg-D-Glu-Gly-D-Cys-D-Val-D-Leu-D-Tyr-D-Leu-D-Ala-D-Glu-D-Val-D-Leu-D-His-D-Ser-Gly-OH
  • Length (aa)
    19
  • Peptide Purity (HPLC)
    95.2
  • Molecular Formula
    C94H140N24O26S
  • Molecular Weight
    2054.32
  • Source
    Synthetic
  • Additional Information
    There is no cure or prevention treatment for Type 1 Diabetes (T1D). Insulin peptide InsB:9-23 (SHLVEALYLVCGERG) and HLA-DQ8 molecule are key elements in T1D development. A retro-inverso-d-amino acid based peptide RI-EXT (ffGGreGcvlylaevlhsG) could block the binding between InsB:9-23 and HLA-DQ8. RI-EXT blocks the presentation of InsB:9-23 to autoreactive T-cells. RI-EXT could lead to innovative therapies for the treatment of T1D.
  • Storage Guidelines
    Ideally RI-EXT should be stored in a freezer at or below -9C. RI-EXT should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Lombardi, A., Concepcion, E., Hou, H., Arib, H., Mezei, M., Osman, R., & Tomer, Y. (2020). Retro-inverso D-peptides as a novel targeted immunotherapy for Type 1 diabetes. Journal of Autoimmunity, 115, 102543.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"