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  • RI-EIP2 (Retroinverso EIP2)

RI-EIP2 (Retroinverso EIP2)

Cat.#: 318862

Size:
Optional Service: TFA RemovalWhat's this?

Special Price 219.6 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    RI-EIP2 (Retroinverso EIP2)
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    H-GRRRQRRKKRGGPLSGFSL-OH
  • Three letter code
    H-D-Gly-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-D-Gly-D-Gly-D-Pro-D-Leu-D-Ser-D-Gly-D-Phe-D-Ser-D-Leu-OH
  • Length (aa)
    19
  • Peptide Purity (HPLC)
    95.2
  • Molecular Formula
    C93H166N40O23
  • Molecular Weight
    2212.56
  • Source
    Synthetic
  • Additional Information
    Retroinverso(RI), RI-EIPs suppress tumor growth, intravasation, and metastasis in vivo. Wang et al. identify peptides that interact with the DNA binding domain of ERG, thereby attenuating protein-protein interactions and chromatin recruitment of ERG and inducing ERG degradation. These peptides reduce proliferation, invasion, and tumor growth of prostate cancer cells with the TMPRSS2:ERG gene fusion.
  • Storage Guidelines
    Ideally RI-EIP2 (Retroinverso EIP2) should be stored in a freezer at or below -9C. RI-EIP2 (Retroinverso EIP2) should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Wang et al., Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer, Cancer Cell (2017).
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"