Rhesus HER3/ErbB3 recombinant protein

Rhesus HER3/ErbB3 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

ERBB-3; HER3; ERBB3; P180-ERBB3; P45-SERBB3; MGC117742; P85-SERBB3; C76256; MDA-BF-1; C-ERBB3; ERBB3-S; LCCS2; MGC88033; C-ERBB-3; ERBB3R

Human Cells

A DNA sequence encoding the rhesus ERBB3 (XP_001113953.2) (Met1-Thr643) was expressed with six amino acids (LEVLFQ) at the C-terminus.

Rhesus

The recombinant rhesus ERBB3 consists 631 amino acids and predicts a molecular mass of 69.5 kDa.

> 90 % as determined by SDS-PAGE.

1. Measured by its binding ability in a functional ELISA.
2. Immobilized Rhesus ERBB3 at 10 μg/mL (100 μL/well) can bind Human Fc-NRG1 (isoform Beta1) (Cat:504011). The EC₅₀ of Human Fc-NRG1 (isoform Beta1) is 0.51-1.19 μg/mL.