Rhesus EphA4/Eph Receptor A4 (His Tag) recombinant protein

Cat.#: 504748

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Product Information

  • Product Name
    Rhesus EphA4/Eph Receptor A4 (His Tag) recombinant protein
  • Documents
  • Description
    EPH receptor A4 (ephrin type-A receptor 4), also known as EphA4, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. EphA4 is enriched on dendritic spines of pyramidal neurons in the adult mouse hippocampus, and ephrin-A3 is localized on astrocytic processes that envelop spines. Eph receptor−mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). The extracellular domain of an EphA4 interacts with ephrin ligands, which may be tethered to neighbouring cells. Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer.
  • Protein short names
    RB; SEK1; CEK8; TYRO1; EPHA4; 2900005C20RIK; AI385584; HEK8; SEK
  • Uniprot ID
    G7N911
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rhesus EPHA4 (NP_001247799.1) (Met1-Thr547) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Rhesus
  • Molecular weight
    The recombinant rhesus EPHA4 comprises 539 amino acids and has a calculated molecular mass of 59.8 KDa.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA.
    Immobilized Rhesus EPHA4-His at 10 μg/ml (100 μl/well) can bind mouse EFNA5-Fc (Cat:502960), The EC50 of mouse EFNA5-Fc (Cat:502960) is 28.2-65.8 ng/ml.
  • Validations

    Cynomolgus EphA4 Protein (His Tag) SDS-PAGE

    Cynomolgus EphA4 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"