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Product Name
Rhesus B7-H5 / GI24 / VISTA (His Tag) recombinant protein
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Description
C10orf54, also known as GI24, belongs to the immunoglobulin superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, C10orf54 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.
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Protein name
Platelet receptor Gi24
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Protein short names
B7H5; SISP1; PP2135; STRESS INDUCED SECRETED PROTEIN 1; GI24; B7-H5; PLATELET RECEPTOR GI24; RP11-472K8.3
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Uniprot ID
F7F6S6
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Gene Name
C10orf54
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rhesus C10orf54 (NP_001177807.1) (Met1-Ala194) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Rhesus
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Molecular weight
The recombinant rhesus C10orf54 consists 173 amino acids and predicts a molecular mass of 19.6 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Rhesus B7-H5 / GI24 / VISTA Protein (His Tag)
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