Mouse Vsir/Dies1/PD-1H/VISTA (His tag) recombinant protein

Mouse Vsir/Dies1/PD-1H/VISTA (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse Platelet receptor Gi24(VISTA) is a transmembrane glycoprotein with homology to B7like immune costimulatory molecules. Mature mouse Gi24 contains a 159 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane segment, and a 97 aa cytoplasmic domain. VISTA promotes both MT1-MMP expression and the MT1-MMP mediated activation of MMP-2. It supports the differentiation of embryonic stem cells (ESC) and enhances BMP-4 induced signaling in ESC, but it is also down-regulated following BMP-4 exposure. It binds to BMP-4 directly and also associates with the type I BMP receptor Activin RIB/ALK-4. It is expressed on the surface of naïve CD4+ T cells and regulatory T cells. It is up-regulated in vivo on activated monocytes and dendritic cells. VISTA inhibits CD4+ and CD8+ T cell proliferation and their production of IL-2 and IFN-γ. Its expression on tumor cells attenuates the antitumor immune response and enables more rapid tumor progression.

V-set immunoregulatory receptor(Vsir)

Dies1; PD-1H; VISTA

Q9D659

Human Cells

A DNA sequence encoding the Mouse Vsir/Dies1/PD-1H/VISTA Phe33-Ala191 is expressed fused with a 6His tag at the C-terminus.

Mouse

>95% as determined by SDS-PAGE.