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Product Name
Human RTN4/NOGO-A (GST Tag) recombinant protein
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Description
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
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Protein name
Reticulon-4
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Protein short names
NOGO-B; RTN4-B2; RTN4-B1; AA960376; AA407876; MKIAA0886; NI220/250; NOGO; MY043; RTN4-C; NOGO-C; MKIAA4153; NSP-CL; KIAA4153; C130026I10RIK; NOGOC; RTN-X; NSP; RTN4-A; ASY; AA409940; NBLA10545; NOGO-A; NBLA00271; RTN4; 1110020G17RIK; RP23-176O5.4
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Uniprot ID
Q9NQC3
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Gene Name
RTN4; KIAA0886; NOGO; My043; SP1507
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human RTN4 (NP_065393.1) N-terminal fragment (Met 1-Val 185) was fused with the GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human RTN4/GST chimera consists of 417 amino acids and has a predicted molecular mass of 46.2 kDa. It migrates as an approxiamtely 48 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 92 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind recombinant human RTN4R in a functional ELISA.
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Validations
Human RTN4 / NOGO-A Protein (GST Tag) SDS-PAGE
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