Renin receptor,ATP6AP2 antibody

Renin receptor,ATP6AP2 antibody

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• Material Safety Data Sheets (MSDS)

Renin receptor,ATP6AP2 Rabbit Polyclonal antibody. Positive IHC detected in human heart tissue. Positive WB detected in mouse eye tissue, human retinal pigment epithelium tissue, Y79 cells. Observed molecular weight by Western-blot: 45-47 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

APT6M8 9 antibody; ATP6AP2 antibody; ATP6IP2 antibody; ATP6M8 9 antibody; CAPER antibody; ELDF10 antibody; HT028 antibody; M8 9 antibody; MRXE antibody; MSTP009 antibody; N14F antibody; PRR antibody; PSEC0072 antibody; Renin receptor antibody; RENIN RECEPTOR antibody; ATP6AP2 antibody; Renin/prorenin receptor antibody; V ATPase M8.9 subunit antibody; XMRE antibody

Rabbit IgG

This antibody was obtained by immunization of Renin receptor,ATP6AP2 recombinant protein (Accession Number: BC010395). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

ATP6AP2, also named as ATP6IP2, CAPER, ELDF10, N14F, ATP6M8-9, Renin receptor and prorenin receptor, is believed to potentiate the renin–angiotensin system (RAS), conferring to prorenin, a likely pathological role at tissue level. The PRR has been identified in the microvascular endothelial cells of the retina, in which it seems to be involved in pathological neovascularization processes. The present study demonstrates for the first time that the PRR is expressed in human ATP6AP2 and suggests a molecular mechanism by which hypertension may exacerbate the pathology of dry AMD. ATP6AP2 functions as a renin and prorenin cellular receptor. It may mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). Defects in ATP6AP2 are a cause of mental retardation X-linked with epilepsy (MRXE). (PMID:19580809)

• Alcazar O, Cousins SW, Striker GE, Marin-Castano ME. (Pro)renin receptor is expressed in human retinal pigment epithelium and participates in extracellular matrix remodeling. Experimental eye research. 89(5):638-47. 2009.