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Product Name
Human Renin (His Tag) recombinant protein
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Description
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
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Protein name
Renin
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Protein short names
REN-A; RN-1; FLJ10761; REN; REN1D; RENIN; REN-1; RNR; REN1C; HNFJ2; D19352
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Uniprot ID
P00797
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Gene Name
REN
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human Renin (NP_000528.1) precursor (Met 1-Arg 406) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The secreted recombinant human Renin is a monomeric protein after cleavage of the signal peptide. The pro form consists of 394 amino acids and predictes a molecular mass of 43.7 kDa. In SDS-PAGE under reducing conditions, it migrates with the apparent molecular mass of 50 kDa due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA.
Immobilized human RENIN-His (Cat: 501755) at 10 μg/ml (100 μl/well) can bind biotinylated human AGT-His (Cat: 501652) with a linear range of 0.156-5.0 μg/ml. -
Validations
Human Renin Protein (His Tag) SDS-PAGE
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