RBP4 antibody

RBP4 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

RBP4 Rabbit Polyclonal antibody. Positive IHC detected in human liver cancer tissue, mouse liver tissue. Positive WB detected in human plasma tissue, human liver tissue, mouse liver tissue, rat liver tissue. Observed molecular weight by Western-blot: 23 kDa

ELISA, IHC, WB

Human,Mouse,Rat; other species not tested.

Plasma retinol binding protein antibody; PRBP antibody; RBP antibody; RBP4 antibody; Retinol binding protein 4 antibody

Rabbit IgG

This antibody was obtained by immunization of RBP4 recombinant protein (Accession Number: NM_006744). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

RBP4 (retinol-binding protein 4) is a carrier protein that transports vitamin A (retinol) from the liver to the peripheral tissues. Synthesized primarily by hepatocytes and adipocytes as a 21 kDa non-glycosylated protein, RBP4 is secreted into the circulation as a retinol-RBP4 complex. In plasma the RBP4-retinol complex is bound to transthyretin (TRR), which prevents prevent kidney filtration. Two truncated forms of RBP4, RBP4-L (truncated at Leu-183) and RBP4-LL (truncated at Leu-182 and Leu-183), exist by proteolytic process. RBP4-L and RBP4-LL, which do not bind TTR, are normally excreted into the urine but accumulate in the serum during renal failure. Urinary RBP4 has been reported as marker for glomerular disease. RBP4 also was identified as an adipokine that elevated in some insulin-resistant states. Measurement of serum RBP4 could be used to assess the risk of insulin resistance, type 2 diabetes, obesity, and cardiovascular disease. (18752671, 16034410)

• Lu CM, Wu YJ, Chen CC. Identification of low-abundance proteins via fractionation of the urine proteome with weak anion exchange chromatography. Proteome science. 9:17. 2011.