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Product Name
RBP2 antibody
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Description
RBP2 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells. Positive IF detected in HeLa cells. Observed molecular weight by Western-blot: 195 kDa
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Tested applications
ELISA, WB, IF
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Histone demethylase JARID1A antibody; JARID1A antibody; KDM5A antibody; lysine (K) demethylase 5A antibody; Lysine specific demethylase 5A antibody; RBBP 2 antibody; RBBP2 antibody; RBP2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_005056). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IF: 1:50-1:500
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:114560(KDM5A antibody) at dilution of 1:500
Immunofluorescent analysis of (10% Formaldehyde) fixed HeLa cells using Catalog No:114560(KDM5A Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
KDM5A, also named as JARID1A, RBBP2 and RBP2, belongs to the JARID1 histone demethylase family. KDM5A is a Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. RBP2 may stimulate transcription mediated by nuclear receptors. It may be involved in transcriptional regulation of Hox proteins during cell differentiation. It may participate in transcriptional repression of cytokines such as CXCL12
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