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Product Name
RBBP8 antibody
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Description
RBBP8 Rabbit Polyclonal antibody. Positive WB detected in mouse testis tissue, A431 cells, Jurkat cells, Raji cells. Observed molecular weight by Western-blot: 120kd
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Tested applications
ELISA, WB
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
RBBP8 antibody; CTIP antibody; RBBP 8 antibody; DNA endonuclease RBBP8 antibody; RIM antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of RBBP8 recombinant protein (Accession Number: NM_203291). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
mouse testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:114593(RBBP8 antibody) at dilution of 1:300
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Background
RBBP8 is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. It functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. It interacted with BRCA1 to form a complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Also it promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations
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