-
Product Name
RBBP6 antibody
- Documents
-
Description
RBBP6 Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells, mouse placenta tissue, Transfected HEK-293 cells. Observed molecular weight by Western-blot: 200kd
-
Tested applications
ELISA, WB
-
Species reactivity
Human, Mouse; other species not tested.
-
Alternative names
DKFZp686P0638 antibody; DKFZp761B2423 antibody; MY038 antibody; P2P R antibody; P2PR antibody; PACT antibody; Protein P2P R antibody; RBBP6 antibody; RBQ 1 antibody; RBQ1 antibody; SNAMA antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of RBBP6 recombinant protein (Accession Number: NM_032626). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:2000
-
Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:114592(RBBP6 antibody) at dilution of 1:400
Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:114592(RBBP6 Antibody) at dilution of 1:500
-
Background
RBBP6 (retinoblastoma binding protein 6) is a multifunctional protein that interacts with both p53 and pRb and has been implicated in mRNA processing. It has also been identified as a putative E3 ubiquitin ligase due to the presence of a RING finger domain [PMID:18851979]. RBBP6 contains an N-terminal ubiquitin-like domain and a cysteine-rich RING finger-like domain, through which it promotes the ubiquitination of p53 by Hdm2 in an E4-like manner [PMID:17470788]. It is implicated in a diverse set of cellular functions, including mRNA metabolism, regulation of the cell cycle, tumorigenesis, and development [PMID:12938151,17470788].
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"