Rat TNFRSF11A (Fc Tag) recombinant protein

Rat TNFRSF11A (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. Defects in TNFRSF11A can cause familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 11A; PDB2; RECEPTOR ACTIVATOR OF NF-KAPPAB; OFE; OSTS; TRANCER; ODFR; RECEPTOR ACTIVATOR OF NF-KB; LY109; FEO; RANK; MRANK; LOH18CR1; TRANCE-R; CD265; OPTB7; OSTEOCLAST DIFFERENTIATION FACTOR RECEPTOR

Human Cells

A DNA sequence encoding the rat TNFRSF11A (Met1-Pro213) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Rat

The recombinant rat TNFRSF11A/Fc is a disulfide-linked homodimer. The reduced monomer comprises 424 amino acids and has a predicted molecular mass of 47.1 kDa. The apparent molecular mass of the protein is approximately 61 kDa in SDS-PAGE under reducing conditions.

> 80 % as determined by SDS-PAGE