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Product Name
Rat HER2/ErbB2 (His Tag) recombinant protein
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Description
Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
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Protein name
Receptor tyrosine-protein kinase erbB-2
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Protein short names
HER-2; C-NEU; RP23-355L10.8; ERBB2; NEU; C-ERBB-2; MLN19; NGL; HER2; MKIAA3023; CD340; ERBB-2; HER-2/NEU; C-ERBB2; TKR1
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Uniprot ID
P06494
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Gene Name
Erbb2; Neu
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat ErbB2 (AAH61863.1) extracellular domain (Met 4-Thr 656) was expressed, fused with a polyhistidine tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat ErbB2 comprises 642 amino acids and predicts a molecular mass of 71.3 kDa. The apparent molecular mass of the rat ErbB2 is approximately 110 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Rat HER2 / ErbB2 Protein (His Tag) SDS-PAGE
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