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Product Name
Rat c-MPL / CD110 / TPOR (His Tag) recombinant protein
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Description
CD110, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number of cells of hematopoietic origin. C-MPL is homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. Thrombopoietin is the ligand for c-mpl. It was shown to be the major regulator of megakaryocytopoiesis and platelet formation. Defects in c-MPL are a cause of congenital amegakaryocytic thrombocytopeniawhich is a disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies. Defects in c-MPL also cause thrombocythemia type 2 and myelofibrosis with myeloid metaplasia.
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Protein short names
MPL; THROMBOPOIETIN RECEPTOR; C-MPL-II; C-MPL-I; MPLV; TPOR; CD110; PROTO-ONCOGENE C-MPL; MYELOPROLIFERATIVE LEUKEMIA VIRUS ONCOGENE; TPO-R; MYELOPROLIFERATIVE LEUKEMIA PROTEIN; C-MPL; THCYT2; RP1-92O14.1; HLB219; RP23-145E1.7
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of rat MPL (Met1-Ala500) was expressed with a polyhistide tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat MPL consists of 490 amino acids and predicts a molecular mass of 55.1 KDa. It migrates as an approximately 55 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Rat c-MPL / CD110 / TPOR Protein (His Tag) SDS-PAGE
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