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  • RASGRP1 Polyclonal Antibody

RASGRP1 Polyclonal Antibody

Cat.#: 160530

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Product Information

  • Product Name
    RASGRP1 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to RASGRP1
  • Tested applications
    WB
  • Species reactivity
    Human
  • Alternative names
    RASGRP1 antibody; CALDAG-GEFI antibody; CALDAG-GEFII antibody; RASGRP antibody; V antibody; hRasGRP1 antibody; RAS guanyl-releasing protein 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 598-797 of human RASGRP1 (NP_005730.2).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:1000 - 1:2000
  • Validations

    Western blot - RASGRP1 Polyclonal Antibody

    Western blot - RASGRP1 Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using RASGRP1 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 5s.

  • Background
    Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"