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RARB antibody

Cat.#: 114468

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Product Information

  • Product Name
    RARB antibody
  • Documents
  • Description
    RARB Rabbit Polyclonal antibody. Positive IF detected in HepG2. Positive IHC detected in human liver cancer.
  • Tested applications
    ELISA, IHC, IF
  • Species reactivity
    human, mouse, rat; other species not tested.
  • Alternative names
    RARB antibody; Retinoic acid receptor beta antibody; RAR epsilon antibody; NR1B2 antibody; RAR beta antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of RARB recombinant protein (Accession Number: NM_000965). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    IHC: 1:20-1:200

    IF: 1:20-1:200

  • Validations

    Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:114468(RARB antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:114468(RARB antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:114468(RARB antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:114468(RARB antibody) at dilution of 1:50 (under 40x lens)

    Immunofluorescent analysis of HepG2 cells, using RARB antibody Catalog No:114468 at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

    Immunofluorescent analysis of HepG2 cells, using RARB antibody Catalog No:114468 at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

  • Background
    Retinoic acid receptors (RARs) are important mediators of retinoid signaling in morphogenesis, development, and cell differentiation. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes [PMID:12554770]. They can bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, they act mainly as activators of gene expression due to weak binding to corepressors. In concert with RARG, RARs are required for skeletal growth, matrix homeostasis and growth plate function. RARB is one isotypes of RARs [PMID:12834868]

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"