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Product Name
RAMP3 antibody
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Description
RAMP3 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue. Positive WB detected in mouse heart tissue, A549 cells, human heart tissue, human kidney tissue, human placenta tissue, Jurkat cells, MCF7 cells, mouse brain tissue, mouse lung tissue, mouse pancreas tissue, mouse skeletal muscle tissue. Observed molecular weight by Western-blot: 50 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
RAMP3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of RAMP3 recombinant protein (Accession Number: NM_005856). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:114535(RAMP3 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:114535(RAMP3 antibody) at dilution of 1:50 (under 10x lens)
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Background
The receptor activity-modifying proteins (RAMPs) and the calcitonin receptor-like receptor (CRLR) are both required to generate adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) receptors. During the process, RAMP3 transport the glycosylated 58-kD CGRPR to the cell surface. The formation of CRLR-RAMP heterodimer is essential for the proper cell surface targeting and pharmacological characteristics of both CGRP and AM receptors.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"