RAD51AP1 antibody

RAD51AP1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

RAD51AP1 Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, mouse liver tissue, rat liver tissue. Observed molecular weight by Western-blot: 38 kDa

ELISA, WB

Human, Mouse, Rat; other species not tested.

PIR51 antibody; RAD51 assOCiated protein 1 antibody; RAD51 interacting protein antibody; RAD51AP1 antibody

Rabbit IgG

This antibody was obtained by immunization of RAD51AP1 recombinant protein (Accession Number: NM_001130862). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Homologous recombination (HR) is an important pathway for the elimination of DNA double-strand breaks (DSBs) and other deleterious lesions from chromosomes. The eukaryotic HR reaction is mediated by RAD51 [PMID:12456786]. RAD51AP1 (RAD51 associated protein 1), so named because it can interact with human RAD51, is a vertebrate-specific protein that enhances the ability of RAD51 to mediate the D-loop reaction. RAD51AP1 knockdown by siRNA leads to cellular sensitivity to DNA damaging agents and elevated DNA damage-induced chromatid breaks. Enhancement of the RAD51 recombinase activity by RAD51AP1 is contingent upon physical interaction of the two HR factors [PMID:17996710,17996711].