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RAD23B antibody

Cat.#: 114514

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Special Price 239.0 USD

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Product Information

  • Product Name
    RAD23B antibody
  • Documents
  • Description
    RAD23B Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer. Positive WB detected in Jurkat cells, HEK-293 cells, A431 cells, mouse kidney tissue. Observed molecular weight by Western-blot: 58kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    human, mouse, rat; other species not tested.
  • Alternative names
    RAD23B antibody; HR23B antibody; HHR23B antibody; P58 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of RAD23B recombinant protein (Accession Number: NM_002874). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:114514(RAD23B antibody) at dilution of 1:200

    Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:114514(RAD23B antibody) at dilution of 1:200

    Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:114514(RAD23B antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:114514(RAD23B antibody) at dilution of 1:50 (under 10x lens)

  • Background
    RAD23B, also named as p58, hHR23B and HR23B, belongs to the RAD23 family. It plays a central role both in proteosomal degradation of misfolded proteins and DNA repair. RAD23B is a central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Involved in DNA excision repair by stabilizing XPC protein. It may play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. RAD23B has two subunit: Heterodimer of a 125 kDa subunit (p125) and of a 58 kDa subunit (p58).
  • References
    • Wear MP, Kryndushkin D, O'Meally R, Sonnenberg JL, Cole RN, Shewmaker FP. Proteins with Intrinsically Disordered Domains Are Preferentially Recruited to Polyglutamine Aggregates. PloS one. 10(8):e0136362. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"