RAD23B antibody

RAD23B antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

RAD23B Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer. Positive WB detected in Jurkat cells, HEK-293 cells, A431 cells, mouse kidney tissue. Observed molecular weight by Western-blot: 58kd

ELISA, WB, IHC

human, mouse, rat; other species not tested.

RAD23B antibody; HR23B antibody; HHR23B antibody; P58 antibody

Rabbit IgG

This antibody was obtained by immunization of RAD23B recombinant protein (Accession Number: NM_002874). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

RAD23B, also named as p58, hHR23B and HR23B, belongs to the RAD23 family. It plays a central role both in proteosomal degradation of misfolded proteins and DNA repair. RAD23B is a central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Involved in DNA excision repair by stabilizing XPC protein. It may play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. RAD23B has two subunit: Heterodimer of a 125 kDa subunit (p125) and of a 58 kDa subunit (p58).

• Wear MP, Kryndushkin D, O'Meally R, Sonnenberg JL, Cole RN, Shewmaker FP. Proteins with Intrinsically Disordered Domains Are Preferentially Recruited to Polyglutamine Aggregates. PloS one. 10(8):e0136362. 2015.