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Rac1 antibody

Cat.#: 114503

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Special Price 239.0 USD

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Product Information

  • Product Name
    Rac1 antibody
  • Documents
  • Description
    Rac1 Rabbit Polyclonal antibody. Positive WB detected in human brain tissue. Observed molecular weight by Western-blot: 20-21 kDa
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    MIG5 antibody; p21 Rac1 antibody; RAC1 antibody; RAC1b antibody; Ras like protein TC25 antibody; TC 25 antibody; TC25 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Rac1 recombinant protein (Accession Number: NM_006908). Purification method: Antigen Affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

  • Validations

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:114503(RAC1 antibody) at dilution of 1:1000

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:114503(RAC1 antibody) at dilution of 1:1000

  • Background
    RAC1b, also named as TC25, belongs to the small GTPase superfamily and Rho family. RAC1 is a plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, it binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles.
  • References
    • Fan YF, Zhang R, Jiang X. The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension. Cardiovascular research. 99(3):395-403. 2013.
    • Wang Y, Kan H, Yin Y. Protective effects of ginsenoside Rg1 on chronic restraint stress induced learning and memory impairments in male mice. Pharmacology, biochemistry, and behavior. 120:73-81. 2014.
    • Zhu H, Zhang H, Jin F. Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma. Oncotarget. 5(11):3455-71. 2014.
    • Deng Z, Huang Z, Yuan M, Yang K, Pang Y. Baculovirus induces host cell aggregation via a Rho/Rok-dependent mechanism. The Journal of general virology. 95(Pt 10):2310-20. 2014.
    • Ying L, Li G, Wei SS. Sanguinarine inhibits Rac1b-rendered cell survival enhancement by promoting apoptosis and blocking proliferation. Acta pharmacologica Sinica. 36(2):229-40. 2015.
    • Wang B, Fang J, Qu L, Cao Z, Zhou J, Deng B. Upregulated TRIO expression correlates with a malignant phenotype in human hepatocellular carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 36(9):6901-8. 2015.
    • Kan H, Hu W, Wang Y. NADPH oxidase-derived production of reactive oxygen species is involved in learning and memory impairments in 16-month-old female rats. Molecular medicine reports. 12(3):4546-53. 2015.
    • Wu J, Meng J, Du Y. RACK1 promotes the proliferation, migration and invasion capacity of mouse hepatocellular carcinoma cell line in vitro probably by PI3K/Rac1 signaling pathway. Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie. 67(4):313-9. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"