RAB8A Polyclonal Antibody

Cat.#: 164159

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Product Information

  • Product Name
    RAB8A Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to RAB8A
  • Tested applications
    WB, IHC, FC
  • Species reactivity
    Human
  • Alternative names
    RAB8A antibody; MEL antibody; RAB8 antibody; ras-related protein Rab-8A antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant protein of human RAB8A
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, pH7.3.
  • Storage instructions
    Store at 4℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IHC 1:50 - 1:100
    FC 1:20 - 1:50
  • Validations

    Western blot - RAB8A Polyclonal Antibody

    Western blot - RAB8A Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using RAB8A antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 90s.

  • Background
    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"