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Product Name
RAB1A antibody
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Description
RAB1A Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, human brain tissue, NIH/3T3 cells, rat brain tissue. Positive IHC detected in human pancreas cancer tissue, human liver tissue. Observed molecular weight by Western-blot: 23 kDa
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Tested applications
ELISA, IHC, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
DKFZp564B163 antibody; RAB1 antibody; RAB1A antibody; Ras related protein Rab 1A antibody; YPT1 antibody; YPT1 related protein antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of RAB1A recombinant protein (Accession Number: NM_004161). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:114416(RAB1A antibody) at dilution of 1:50 (under 10x lens)
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:114416(RAB1A Antibody) at dilution of 1:1000
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Background
Rab1A is a member of the Rab family of small GTPases with a well characterized function in the regulation of vesicle trafficking from the endoplasmic reticulum to the Golgi apparatus and within Golgi compartments. Rab1A has recently been reported an mTORC1 activator and a colorectal oncogene (Janice D. Thomas. et al. 2014. Cancer cell).
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References
- Thomas JD, Zhang YJ, Wei YH. Rab1A is an mTORC1 activator and a colorectal oncogene. Cancer cell. 26(5):754-69. 2014.
- Gautam M, Jara JH, Sekerkova G, Yasvoina MV, Martina M, Özdinler PH. Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms. Human molecular genetics. 25(6):1074-87. 2016.
- Campbell-Valois FX, Trost M, Chemali M. Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome. Molecular & cellular proteomics : MCP. 11(7):M111.016378. 2012.
- Smith GA, Rocha EM, McLean JR. Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Human molecular genetics. 23(17):4510-27. 2014.
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