Q11 peptide
Not For Human Use, Lab Use Only.
Cat.#: 319745
Special Price 101.7 USD
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Product Name
Q11 peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
Ac-QQKFQFQFEQQ-NH2
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Sequence
Ac-Gln-Gln-Lys-Phe-Gln-Phe-Gln-Phe-Glu-Gln-Gln-NH2
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Length (aa)
11
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Peptide Purity (HPLC)
95.65%
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Molecular Formula
C70H99N19O20
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Molecular Weight
1526.64
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Source
Synthetic
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Form
Powder
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Description
- Q11 polypeptide (QQKFQFQFEQQ) is a beta-sheet fibrillizing peptide. This polypeptide is capable of self-assembling into fibrils and forming hydrogels, which can serve as matrices for various cell types. It allows for the incorporation of ligands such as RGDS and IKVAV through co-assembly with other peptides. The ligand display can be adjusted simply by mixing different peptides in solution and inducing gelation.
- Q11-based gels have shown minimal cytotoxicity and immunogenicity, making them suitable for in vitro and potentially in vivo applications. They also exhibit stable fibrillization and mechanical properties that are minimally affected by ligand incorporation, enabling independent control over ligand presentation and gel mechanics. Overall, Q11 polypeptide offers a modular and tunable platform for designing biomaterials that can direct cellular responses and has potential uses in areas such as regenerative medicine and cell culture.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- Jung JP, Nagaraj AK, Fox EK, Rudra JS, Devgun JM, Collier JH. Co-assembling peptides as defined matrices for endothelial cells. Biomaterials. 2009 Apr;30(12):2400-10. doi: 10.1016/j.biomaterials.2009.01.033. Epub 2009 Feb 8. PMID: 19203790; PMCID: PMC2677558.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"