PXR antibody

PXR antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PXR Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, A549 cells, MCF7 cells, mouse colon tissue. Positive IP detected in HepG2 cells. Observed molecular weight by Western-blot: 45-50kd

ELISA, WB, IP

Human,Mouse,Rat; other species not tested.

BXR antibody; NR1I2 antibody; ONR1 antibody; Orphan nuclear receptor PAR1 antibody; Orphan nuclear receptor PXR antibody; PAR antibody; PAR1 antibody; PAR2 antibody; PARq antibody; Pregnane X receptor antibody; PRR antibody; PXR antibody; SAR antibody; SXR antibody

Rabbit IgG

This antibody was obtained by immunization of PXR recombinant protein (Accession Number: NM_003889). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, plays a key role in the induction of genes involved in drug transport and metabolism. It modulates drug transport and metabolism through the regulation of target genes responsible for the transport and conversion of chemicals into metabolites that are more easily eliminated from the body [PMID: 22609277]. It is also emerging as an endobiotic receptor that regulates the inflammatory response. In addition, PXR acts as a transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds [PMID: 19297428].

• Zhou W, Lin J, Chen H, Wang J, Liu Y, Xia M. Retinoic acid induces macrophage cholesterol efflux and inhibits atherosclerotic plaque formation in apoE-deficient mice. The British journal of nutrition. 114(4):509-18. 2015.