Cynomolgus Hemojuvelin / HFE2 (His Tag) recombinant protein

Cynomolgus Hemojuvelin / HFE2 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Hemojuvelin, also known as HFE2, is a membrane-bound and soluble protein which belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homologue of the Netrin receptor deleted in colon cancer. In mammals, RGM family consists of three glycoproteins which have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH).

Putative uncharacterized protein

AI414844; HAEMOJUVELIN; 2310035L15RIK; MGC23953; HEMOCHROMATOSIS TYPE 2 PROTEIN HOMOLOG; REPULSIVE GUIDANCE MOLECULE C; AI789733; HEMOJUVELIN; RGMC; HJV; HFE2A; RGM DOMAIN FAMILY MEMBER C; JH; HEMOCHROMATOSIS TYPE 2 PROTEIN; DL-M; 5230400G09RIK

G7MG34

EGK_01186

Baculovirus-Insect Cells

A DNA sequence encoding the cynomolgus HFE2 (EHH15137.1) (Met1-Ser400) was expressed with a polyhistidine tag at the C-terminus.

Cynomolgus

The recombinant cynomolgus HFE2 comprises 376 amino acids and has a calculated molecular mass of 40.2 KDa. The apparent molecular mass of the protein is approximately 32 KDa in SDS-PAGE.

> 95 % as determined by SDS-PAGE