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Product Name
PTP4A1/PRL1 antibody
- Documents
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Description
PTP4A1/PRL1 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue. Positive WB detected in MCF7 cells. Observed molecular weight by Western-blot: 22kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
DKFZp779M0721 antibody; HH72 antibody; PRL 1 antibody; PRL1 antibody; PTP(CAAX1) antibody; PTP(CAAXI) antibody; PTP4A1 antibody; PTPCAAX1 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PTP4A1/PRL1 recombinant protein (Accession Number: XM_017011270). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
MCF7 cells were subjected to SDS PAGE followed by western blot with Catalog No:114311(PTP4A1 antibody) at dilution of 1:800
Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:114311(PTP4A1 antibody) at dilution of 1:50 (under 10x lens)
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Background
PTP4A1(protein tyrosine phosphatase type IVA, member 1), also named as PRL1, HH72, PRL-1, PTP(CAAX1), PTPCAAX1, DKFZp779M0721, belongs to the protein-tyrosine phosphatase family, which play an important role in maintaining appropriate tyrosine phosphorylation levels in the cell during development and tissue regeneration(PMID:19341304). PTP4A1 is a PTPase and that it is highly expressed in growing hepatic cells and some tumor cell lines and is located primarily in the cell nucleus, and its overexpression modulates the growth of cells(PMID:8196618).
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References
- Zhou C, Liu G, Wang L. MiR-339-5p regulates the growth, colony formation and metastasis of colorectal cancer cells by targeting PRL-1. PloS one. 8(5):e63142. 2013.
- Zhou C, Lu Y, Li X. miR-339-3p inhibits proliferation and metastasis of colorectal cancer. Oncology letters. 10(5):2842-2848. 2015.
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