PTCH2 antibody

PTCH2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PTCH2 Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, human brain tissue. Positive IHC detected in human brain tissue. Observed molecular weight by Western-blot: 131-140 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

patched homolog 2 (Drosophila) antibody; Protein patched homolog 2 antibody; PTC2 antibody; PTCH2 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_003738). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PTCH1 (patched homolog 1) and PTCH2 are twelve-pass transmembrane proteins that act receptors of Hedgehog signaling pathway (PMID: 8906794; 9811851). Signals of Hedgehog family proteins (SHH, IHH and DHH in humans) are transduced through Patched family receptors (PTCH1 and PTCH2) and Smoothened (SMO) to GLI family transcription factors. Hedgehog pathway plays a critical role in embryonic development and tissue homeostasis, and its dysregulation has been implicated in many human diseases including congenital disorder and cancer (PMID: 23719536; 23532857). PTCH2 may function as a tumor suppressor in the Hedgehog signaling pathway. Alterations in PTCH2 gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. This antibody is specific to PTCH2.