PTCH1 Polyclonal Antibody

Cat.#: 160160

Special Price 174.2 USD

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Product Information

  • Product Name
    PTCH1 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to PTCH1
  • Tested applications
    WB, IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    PTCH1 antibody; BCNS antibody; HPE7 antibody; NBCCS antibody; PTC antibody; PTC1 antibody; PTCH antibody; PTCH11 antibody; patched 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1214-1312 of human PTCH1 (NP_000255.2).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:1000
    IF 1:50 - 1:200
  • Validations

    Western blot - PTCH1 Polyclonal Antibody

    Western blot - PTCH1 Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using PTCH1 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 90s.

    Immunofluorescence - PTCH1 Polyclonal Antibody

    Immunofluorescence - PTCH1 Polyclonal Antibody

    Immunofluorescence analysis of C6 cells using PTCH1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

    Immunofluorescence - PTCH1 Polyclonal Antibody

    Immunofluorescence - PTCH1 Polyclonal Antibody

    Immunofluorescence analysis of C6 cells using PTCH1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

    Immunofluorescence - PTCH1 Polyclonal Antibody

    Immunofluorescence - PTCH1 Polyclonal Antibody

    Immunofluorescence analysis of mouse embryos cells using PTCH1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

    Immunofluorescence - PTCH1 Polyclonal Antibody

    Immunofluorescence - PTCH1 Polyclonal Antibody

    Immunofluorescence analysis of C6 cells using PTCH1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

    Immunofluorescence - PTCH1 Polyclonal Antibody

    Immunofluorescence - PTCH1 Polyclonal Antibody

    Immunofluorescence analysis of mouse embryos cells using PTCH1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

  • Background
    Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"