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Product Name
PSTPIP1 antibody
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Description
PSTPIP1 Rabbit Polyclonal antibody. Positive WB detected in mouse thymus tissue. Positive IHC detected in human brain tissue. Observed molecular weight by Western-blot: 45-48kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CD2 binding protein 1 antibody; CD2BP1 antibody; CD2BP1L antibody; CD2BP1S antibody; H PIP antibody; PAPAS antibody; PSTPIP antibody; PSTPIP1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PSTPIP1 recombinant protein (Accession Number: NM_003978). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
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Validations
mouse thymus tissue were subjected to SDS PAGE followed by western blot with Catalog No:114255(PSTPIP1 antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human brain using Catalog No:114255(PSTPIP1 antibody) at dilution of 1:50 (under 40x lens)
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Background
PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1), also known as CD2BP1, is a cytoskeleton-associated adaptor protein that links PEST-type phosphatases to their substrates (PMID: 19584923). It is involved in regulation of the actin cytoskeleton. Preferentially expressed in hematopoetic tissues, PSTPIP1 binds to the cytoplasmic tail of CD2, negatively affecting CD2-triggered T cell activation (PMID: 16670297). It has also been shown to interact with ABL1, PTPN18, WAS, CD2AP, PTPN12 and MEFV/pyrin. Mutations in the gene of PSTPIP1 cause PAPA syndrome (Pyogenic sterile Arthritis, Pyoderma gangrenosum, and Acne), an autoinflammatory disease (PMID:11971877; 14595024).
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