PSME1 antibody

PSME1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PSME1 Rabbit Polyclonal antibody. Positive WB detected in mouse spleen tissue. Observed molecular weight by Western-blot: 29-33kd

ELISA, WB

Human,Mouse,Rat; other species not tested.

IFI5111 antibody; IGUP I 5111 antibody; PA28A antibody; PA28alpha antibody; PSME1 antibody; REG alpha antibody; REGalpha antibody

Rabbit IgG

This antibody was obtained by immunization of PSME1 recombinant protein (Accession Number: NM_006263). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The principal function of the proteasome is targeted degradation of intracellular proteins. Activity of the 20S proteasome is controlled by regulatory complexes that bind to the ends of the cylindrical proteasome. 11S regulator (REG or PA28), is a complex of 28 kDa subunits that is thought to activate proteasomes toward the production of antigenic peptides. Human PSME1 and PSME2 genes encode the two proteasome activators PA28 alpha and beta, respectively, which have been implicated in antigen processing for loading class I MHC molecules. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

• Zhao D, Liang L, Li Y. Proteomic analysis of the lungs of mice infected with different pathotypes of H5N1 avian influenza viruses. Proteomics. 12(12):1970-82. 2012.