-
Product Name
PSEN2-Specific antibody
- Documents
-
Description
PSEN2-Specific Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue, human breast cancer tissue, human colon tissue, human placenta tissue.
-
Tested applications
ELISA, IHC
-
Species reactivity
Human, Mouse; other species not tested.
-
Alternative names
AD3L antibody; AD3LP antibody; AD4 antibody; AD5 antibody; E5 1 antibody; Presenilin 2 antibody; PS 2 antibody; PS2 antibody; PSEN2 antibody; PSNL2 antibody; STM 2 antibody; STM2 antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_000447). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
IHC: 1:20-1:200
-
Validations
Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:114300(PSEN2-Specific Antibody) at dilution of 1:200 (under 10x lens)
Immunohistochemistry of paraffin-embedded human kidney tissue slide using Catalog No:114300(PSEN2-Specific Antibody) at dilution of 1:200 (under 40x lens)
-
Background
Presenilins can regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. These transmembrane proteins are considered to be involved in early onset of Alzheimer's disease. Presenilin 2 mainly localizes in large neurons. It exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (about 23 kDa) fragments.This antibody is specific to presenilin 2. It will not bind presenilin 1.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"