PSEN1 antibody

PSEN1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PSEN1 Rabbit Polyclonal antibody. Positive IF detected in HEK-293 cells.

ELISA, IF

Human; other species not tested.

AD3 antibody; FAD antibody; presenilin 1 antibody; Protein S182 antibody; PS 1 antibody; PS1 antibody; PS1 CTF12 antibody; PSEN1 antibody; PSNL1 antibody; S182 antibody

Rabbit IgG

This antibody was obtained by immunization of PSEN1 recombinant protein (Accession Number: NM_007318). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PSEN1(presenilin-1) is also named as AD3, PS1, PSNL1 and belongs to the peptidase A22A family. It directly influences Netrin/DCC signaling with cell type precision and spatiotemporal specificity, and is a key neural circuit builder that gates the spatiotemporal pattern of guidance signaling, thereby ensuring neural projections occur with high fidelity(PMID:21215373). The 46-kDa PSEN1 holoprotein is cleaved into a D30-kDa N-terminal fragment (NTF) and a D20-kDa C-terminal fragment (CTF) by the 26S proteasome(PMID:10527805). It has 7 isoforms produced by alternative splicing. This antibody can recognize the isoform 4 (21 kDa) of this protein except the others.