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  • Ps-CATH4 peptide

Ps-CATH4 peptide

For research use only. We do not sell to patients.

Cat.#: 318769

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Optional Service: TFA RemovalWhat's this?

Special Price 275.2 USD

Availability: 4 weeks
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Product Information

  • Product Name
    Ps-CATH4 peptide
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    H-TRGRWGRFKRRAGRFIRRNRWQIISTGLKLIG-OH
  • Three letter code
    H-Thr-Arg-Gly-Arg-Trp-Gly-Arg-Phe-Lys-Arg-Arg-Ala-Gly-Arg-Phe-Ile-Arg-Arg-Asn-Arg-Trp-Gln-Ile-Ile-Ser-Thr-Gly-Leu-Lys-Leu-Ile-Gly-OH
  • Length (aa)
    32
  • Peptide Purity (HPLC)
    95.2
  • Molecular Formula
    C175H291N65O38
  • Molecular Weight
    3913.58
  • Source
    Synthetic
  • Additional Information
    Cathelicidins are a class of gene-encoded immune effectors in vertebrate innate immune system. Ps-CATH4 is a novel cathelicidin which was found in Chinese soft-shell turtle (Pelodiscus sinensis). Ps-CATH4 was expressed in lung, spleen, liver, kidney, muscle, stomach and intestine. Ps-CATH4 showed the most potent and broad-spectrum antimicrobial activities against the tested pathogens, with the MICs mainly ranging from 2.34 μg/ml to 18.75 μg/ml. Ps-CATH6 showed relatively low antimicrobial activity. Ps-CATH4 and 6 showed relatively low cytotoxicity towards RAW264.7 cells, inducing 15.95% and 10.98% cell death, respectively. Ps-CATH4 showed more potent membrane permeabilization effect than Ps-CATH6, which is consistent with their different antimicrobial activities.
  • Storage Guidelines
    Ideally Ps-CATH4 peptide should be stored in a freezer at or below -9C. Ps-CATH4 peptide should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Shi N, Cai S, Gao J, et al. Roles of polymorphic cathelicidins in innate immunity of soft-shell turtle, Pelodiscus sinensis. Dev Comp Immunol. 2019
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

  • Analysed Sequence:H-TRGRWGRFKRRAGRFIRRNRWQIISTGLKLIG-OH
  • Chemical Formula:C175H291N65O38
  • Sequence length:32
  • Extinction coefficient:11380 M-1cm-1
  • GRAVY:-0.88
  • Mw average:3913.58
  • Theoretical pI:13.3
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"