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Product Name
PRR14 antibody
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Description
PRR14 Rabbit Polyclonal antibody. Positive WB detected in MCF-7 cells, HL-60 cells, mouse brain tissue. Observed molecular weight by Western-blot: 64 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
DKFZp781A13198 antibody; proline rich 14 antibody; Proline rich protein 14 antibody; PRR14 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PRR14 recombinant protein (Accession Number: NM_024031). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
MCF-7 cells were subjected to SDS PAGE followed by western blot with Catalog No:114242(PRR14 Antibody) at dilution of 1:1000
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Background
PRR14 (proline-rich protein 14) is a 585-amino acid protein with a calculated molecular weight of 64 kDa. This protein functions to tether heterochromatin to the nuclear periphery during interphase, through associations with heterochromatin protein 1 (HP1) and the nuclear lamina. After disassembly early in mitosis, PRR14 reassembles in two steps, first binding to anaphase chromosomes through HP1, followed by association with the nuclear lamina in telophase. PRR14 may thereby play a role in specifying HP1-bound heterochromatin for reattachment to the nuclear lamina at mitotic exit. (PMID: 24209742; 24637393)
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