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Product Name
PRPH2 antibody
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Description
PRPH2 Rabbit Polyclonal antibody. Positive IF detected in mouse Retina tissue. Positive WB detected in mouse eye tissue. Observed molecular weight by Western-blot: 39 kDa
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Tested applications
ELISA, WB, IF
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
AOFMD antibody; AVMD antibody; Peripherin 2 antibody; PRPH antibody; PRPH2 antibody; rd2 antibody; RDS antibody; RP7 antibody; Tetraspanin 22 antibody; Tspan 22 antibody; TSPAN22 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PRPH2 recombinant protein (Accession Number: NM_000322). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IF: 1:20-1:200
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Validations
mouse eye tissue were subjected to SDS PAGE followed by western blot with Catalog No:114236(PRPH2 antibody) at dilution of 1:1000
IF result of anti-PRPH2(Catalog No:114236) in Mouse Retina by Dr. Seongjin Seo. OS(Outer segment) Stain.
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Background
Peripherin-2 (PRPH2), also known as retinal degeneration slow protein (RDS), is a photoreceptor-specific tetraspanin protein implicated in outer segment disk morphogenesis. It may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Mutations in peripherin-2 are responsible for various retinal degenerative diseases including autosomal dominant retinitis pigmentosa (ADRP).
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References
- Singh MS, Charbel Issa P, Butler R. Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation. Proceedings of the National Academy of Sciences of the United States of America. 110(3):1101-6. 2013.
- Zhang Y, Seo S, Bhattarai S. BBS mutations modify phenotypic expression of CEP290-related ciliopathies. Human molecular genetics. 23(1):40-51. 2014.
- Datta P, Allamargot C, Hudson JS. Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome. Proceedings of the National Academy of Sciences of the United States of America. 112(32):E4400-9. 2015.
- Shirai H, Mandai M, Matsushita K. Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 113(1):E81-90. 2016.
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