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Product Name
Rat 4-1BBL / CD137L (His Tag) recombinant protein
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Description
4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
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Protein name
Protein Tnfsf9
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Protein short names
AI848817; TNFSF9; LY63L; 4-1BBL; CD137L; 4-1BB-L
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Uniprot ID
Q80WE6
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Gene Name
Tnfsf9; rCG_44980
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat TNFSF9 (Q80WE6) (Pro106-Gly308) was expressed, fused with a polyhistidine tag at the N-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat TNFSF9 comprises 223 amino acids and has a predicted molecular mass of 24.8 kDa. The apparent molecular mass of the protein is approximately 35 kDa in SDS-PAGE under reducing conditions.
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Purity
> 88 % as determined by SDS-PAGE
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Validations
Rat 4-1BBL / CD137L / TNFSF9 Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"