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Mouse Serpinb3c (His Tag) recombinant protein

Cat.#: 501340

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Special Price 621.5 USD

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Product Information

  • Product Name
    Mouse Serpinb3c (His Tag) recombinant protein
  • Documents
  • Description
    Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors). Over 1000 serpins have been identified. Mouse SerpinB3, also known as Squamous cell carcinoma antigen 1, SCCA-1, SERPINB3, SCCA and SCCA1, is a cytoplasm protein which belongs to the serpin family and Ov-serpin subfamily. SerpinB3 may act as a protease inhibitor to modulate the host immune response against tumor cells. Mouse SerpinB3a and SerpinB3b, but not Serpinb3c, are functional, inhibiting both serine and cysteine proteinases with different inhibitory profiles due to the difference of two amino acids in their reactive site loops. SerpinB3a is ubiquitously expressed in most tissues, whereas expression of SerpinB3b is limited to keratinocytes. SerpinB3a and SerpinB3b may play different roles by inhibiting intrinsic or extrinsic proteinases with different expression distributions and different inhibitory profiles.
  • Protein name
    Protein Serpinb3c
  • Protein short names
    SCCA2; 1110001H02RIK; SERPINB4; 1110013A16RIK
  • Uniprot ID
    Q9D1E7
  • Gene Name
    Serpinb3c
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse SERPINB3C (NP_958751.2) (Met 1-Pro 386) was expressed, with a C-terminal polyhistidine tag.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse SERPINB3C consists of 397 amino acids and has a calculated molecular mass of 46.5 kDa. The apparent molecular mass of the protein is approximately 46 & 95 kDa in SDS-PAGE under reducing conditions, corresponding to the monomer and dimer.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Mouse Serpinb3c Protein (His Tag) SDS-PAGE

    Mouse Serpinb3c Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"