Human S100A9 recombinant protein

Cat.#: 502215

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Product Information

  • Product Name
    Human S100A9 recombinant protein
  • Documents
  • Description
    S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A9, also known as S100 calcium-binding protein A9, S100A9, and CAGB, is a member of the S-100 family. S100A9 is expressed by macrophages in acutely inflammed tissues and in chronic inflammation. It is also expressed in epithelial cells constitutively or induced during dermatoses. S100A9 is a calcium-binding protein. It has anti-microbial activity towards bacteria and fungi. The anti-microbial and proapoptotic activity of S100A9 is inhibited by zinc ions. S100A9 plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). It promotes tubulin polymerization when unphosphorylated. It also promotes phagocyte migration and infiltration of granulocytes at sites of wounding. S100A9 plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1.
  • Protein name
    Protein S100-A9
  • Protein short names
    GAGB; 60B8AG; MRP-14; CFAG; BEE22; CAGB; MIF; CGLB; MAC387; MRP14; NIF; S100A9; AW546964; LIAG; L1AG; P14
  • Uniprot ID
    P06702
  • Gene Name
    S100A9; CAGB; CFAG; MRP14
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the native form of human S100A9 (NP_002956.1) (Met 1-Pro 114) was expressed.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human S100A9 consisting of 114 amino acids and migrates with an apparent molecular mass of 26 & 13 kDa corresponding to dimeric and monomeric form as estimated in SDS-PAGE under Non-reduced condition.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    This product displays no activity in cell-based assay.
  • Validations

    Human S100A9 / CAGB / P14 Protein SDS-PAGE

    Human S100A9 / CAGB / P14 Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"