PRKG1 antibody

PRKG1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PRKG1 Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in rat brain tissue, mouse brain tissue. Observed molecular weight by Western-blot: 65-78 kDa

ELISA, WB, IP

Human, Rat, Mouse; other species not tested.

cGK 1 antibody; cGK1 antibody; CGKI antibody; cGKI alpha antibody; cGKI BETA antibody; DKFZp686K042 antibody; FLJ36117 antibody; PGK antibody; PKG antibody; PRKG1 antibody; PRKG1B antibody; PRKGR1A antibody; PRKGR1B antibody; Protein Kinase G1 alpha antibody

Rabbit IgG

This antibody was obtained by immunization of PRKG1 recombinant protein (Accession Number: NM_006258). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PRKG1(cGMP-dependent protein kinase 1) is also named as cGK1, PRKG1B, PRKGR1A, PRKGR1B and belongs to the cGMP subfamily. It serves as an integral component of second messenger signaling in a number of biological contexts including cell differentiation, memory, and vasodilation(PMID:21893290). Its activity prevents pathological-level nitric oxide-induced apoptosis and promotes DNA synthesis/cell proliferation in vascular smooth muscle cells(PMID:20060325). PRKG1 has 2 isoforms produced by alternative splicing with the molecular weight of 76 kDa and 78 kDa. The autophosphorylation can increase the kinase activity and it can form a monomer with the molecular weight of 65 kDa that is produced by proteolytic cleavage. SDS-PAGE revealed that proteolysis generated two different monomers with molecular masses of 70 and 68 kDa of CGK1-beta(PMID:8702828).