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Product Name
Prealbumin/transthyretin antibody
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Description
Prealbumin/transthyretin Mouse Monoclonal antibody. Positive IHC detected in human liver tissue. Positive WB detected in Human brain. Observed molecular weight by Western-blot: 16 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
ATTR antibody; HsT2651 antibody; PALB antibody; Prealbumin antibody; Prealbumin/transthyretin antibody; TBPA antibody; transthyretin antibody; TTR antibody
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Isotype
Mouse IgG2a
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Preparation
This antibody was obtained by immunization of Prealbumin/transthyretin recombinant protein (Accession Number: NM_000371). Purification method: Protein A purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:107483(TTR antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver tissue slide using Catalog No:107483(TTR Antibody) at dilution of 1:50
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Background
Transthyretin (TTR) is a plasma transport protein for thyroxine and retinol, through the association with retinol-binding protein. It is a homotetrameric protein synthesized mainly in liver, choroid plexus, retinal pigment epithelium, and pancreas.Within the CNS, TTR is the only known protein synthesized solely by the choroid plexus. Mutant and wildtype TTR give rise to various forms of amyloid deposition (amyloidosis). Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR),hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) and carpal tunnel syndrome type 1 (CTS1). In addition, positive immunostaining for TTR has been reported as a sensitive diagnostic marker of choroid plexus tumors. (22103483)
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