Pre-S2 (1-26) peptide
Not For Human Use, Lab Use Only.
Cat.#: 315986
Special Price 328.9 USD
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Product Name
Pre-S2 (1-26) peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
MQWNSTAFHQTLQDPRVRGLYLPAGG
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Sequence
H-Met-Gln-Trp-Asn-Ser-Thr-Ala-Phe-His-Gln-Thr-Leu-Gln-Asp-Pro-Arg-Val-Arg-Gly-Leu-Tyr-Leu-Pro-Ala-Gly-Gly-OH
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Length (aa)
26
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Peptide Purity (HPLC)
97.8%
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Molecular Formula
C131H199N39O37S
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Molecular Weight
2944.33
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Source
Synthetic
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Form
Powder
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Description
This synthetic peptide comprises the N-terminal portion of a 55-residue sequence encoded by the pre-S2 region of hepatitis B virus (HBV) DNA. It represents an immunodominant epitope, and the immunogenicity can be enhanced by covalently linking the peptide to liposomes. Antibodies elicited against this determinant recognize envelope epitopes common to several subtypes of HBV and HBsAg particles. Because these antibodies show virusneutralizing activity in vivo, pre-S (120-145) has the potential as
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- A.R.Neurath et al., Science, 224, 392 (1984)
- A.R.Neurath et al., J. Virol. Meth., 12, 185 (1985)
- A.R.Neurath et al., Nature, 315, 154 (1985)
- A.R.Neurath et al., Vaccine, 4, 35 (1986)
- A.R.Neurath et al., Synthetic Peptides Approaches to Biological Problems, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 86, p. 143, Alan R.Liss, New York, (1989)
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Peptide Property
- Analysed Sequence:H-MQWNSTAFHQTLQDPRVRGLYLPAGG-OH
- Chemical Formula:C131H199N39O37S
- Sequence length:26
- Extinction coefficient:6970 M-1cm-1
- GRAVY:-0.56
- Mw average:2944.27
- Theoretical pI:9.84
- Data Source:Peptide Property Calculator
GRAVY = grand average of hydropathy
X: Hydrophobic uncharged residues, like F I L M V W A and P
X: Basic residues, like R K H
X: Acidic residues, like D E
X: Polar uncharged residues, like G S T C N Q and Y
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"