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Human WTAP (GST Tag) recombinant protein

Cat.#: 501748

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Product Information

  • Product Name
    Human WTAP (GST Tag) recombinant protein
  • Documents
  • Description
    Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
  • Protein name
    Pre-mRNA-splicing regulator WTAP
  • Protein short names
    MGC3925; WTAP 2810408K05RIK; MUM2; 9430038B09RIK; RP1-56L9.4; WTAP; DKFZP686F20131; 2810408K05RIK; KIAA0105
  • Uniprot ID
    Q15007
  • Gene Name
    WTAP; KIAA0105
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human WTAP isoform 2 (Q15007-2) (Met 1-Arg 151) was fused with the GST tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human WTAP/GST chimera consists of 386 amino acids and migrates as an approxiamtely 45 kDa band as predicted in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Human WTAP Protein (GST Tag) SDS-PAGE

    Human WTAP Protein (GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"